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Our student is a laureate of the BioLAB program!!!
Mr. Marcin Ostoja-Hełczyński, conducting his research under the supervision of Prof. Ewa Zuba-Surma, have been selected as laureates of the BioLAB program. The BioLAB program is a year-long internship for students of biological-chemical, biophysical, medical, and related sciences in four American scientific institutions. Mr. Marcin will conduct his research under the guidance of Dr. Jake Kirkland at the Oklahoma Medical Research Foundation, investigating the impact of chromatin regulators on the development of heart cells and the maintenance of the heart stem cell population in mice. Congratulations!!!

Our publication in the prestigious Journal of Nanobiotechnology (IF=10.2)!!!

Our Team has published an article in the "Journal of Nanobiotechnology" (IF2023=10.2). The work was a result of Polish-French collaboration between teams from WBBiB UJ and INSERM.

The first authors of the publication entitled "Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1" are Dr. Anna Łabędź-Masłowska and Dr. Luisa Vergori. The research involved Anna Łabędź-Masłowska, Elżbieta Karnas, Sylwia Bobis-Wozowicz and Ewa Zuba-Surma from the Department of Cell Biology, as well as Syliwa Kędracka-Krok from the Department of Physical Biochemistry and Michał Sarna from the Department of Biophysics at WBBiB. The article can be accessed on the publisher's website. The publication of the article in open access mode was made possible thanks to funding from WBBiB UJ as part of the Strategic Excellence Initiative at Jagiellonian University.


The BioMiStem Project team awarded in the 21st edition of the Economic Award of the President of the Republic of Poland!!!
Our interdisciplinary team of the BioMiStem Project under the direction of Prof. Ewa Zuby-Surma, consisting of scientists from the Faculty of Biochemistry, Biophysics and Biotechnology of the Jagiellonian University in Krakow and researchers from the Galen-Orthopedics Clinic in Bierun, has developed a new "cell therapy" called MesoCellA-Ortho. This is an innovative advanced therapy medicinal product (ATMP), with its active substance being human autologous mesenchymal cells prepared under GMP conditions. The product is dedicated for use in orthopedics, in the treatment of cartilage and bone defects in patients with degenerative joint disease, which is a global civilizational problem. Congratulations and best wishes for further success!

Prof. Ewa Zuba-Surma was awarded with the prestigious Kościuszko Foundation fellowship!!!
Prof. Ewa Zuba-Surma was awarded with the prestigious Kościuszko Foundation fellowship, which enables scientists, experts and artists to carry out postdoctoral research in the USA. As part of the fellowship, Prof. Zuba-Surma will go to the University of Nevada in order to conduct research on the pre-regenerative role of extracellular vesicles – EVs, secreted by human stem cells obtained from various sources. The nomination was presented to her by the US Ambassador to Poland Mark Brzezinski and the Kościuszko Foundation President and Executive Director Marek Skulimowski. więcej o

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Welcome on our page!

Welcome to the MicroTeam website led by Prof. dr. hab. Ewa Zuba-Surma. The work conducted in our team focuses on the use of stem cells (SCs) in regenerative medicine, especially in repairing ischemic damage of the heart muscle and other peripheral organs. The team is currently carrying out several research grants, working on both animal and human material.

MicroTeam is currently conducting projects in the Cell Biology Department of the Faculty of Biochemistry, Biophysics, and Biotechnology at the Jagiellonian University. The research involves stem cells and their bioactive derivatives. The team has experience in:

  • isolating and culturing stem cells (SCs) derived from bone marrow, umbilical cord blood, Worthen's jelly, mobilized peripheral blood, and other mature tissues – from which hematopoietic SCs [HSC], VSELs, Mesenchymal SCs [MSC], Endothelial Progenitor SCs [EPC], among others, are obtained;
  • genetic induction aimed at obtaining iPS cells – the group has its own human and animal iPS cell lines, and has the capability to obtain these lines from any cells through transfection or transduction (including their own production line of viral vectors);
  • isolating and assessing bioproducts of SCs, including bioactive microvesicles (MVs) derived from SCs and other clinical materials (including peripheral blood, umbilical cord blood, and bone marrow);
  • identifying SCs and their derivatives in experimental (including animal) and clinical material based on the antigenic profile of these cells using state-of-the-art flow cytometry technologies (both classical and imaging);
  • testing the functional potential of SCs in vitro (including proliferative activity, viability, cardiomyogenic and angiogenic differentiation) and in vivo (in collaboration: the ability to study the regenerative activity of selected SCs in models of heart and limb ischemia in small and large preclinical animal models – respectively, in mice and pigs).

The research conducted by our team is carried out using top-class research equipment, including the use of modern multicolor flow cytometers for cell analysis, as well as nanoparticles. We have a fully equipped cell culture laboratory capable of culturing cells under standard conditions or under reduced oxygen conditions, which is utilized in working with stem cells. The laboratory allows for cultivation of SCs from various species at the highest standard, with the possibility of using them in further studies and potential practical applications. The laboratory also enables optimization of the methods used, for example, to study the impact of biomaterials, biopolymers, or soluble factors on SC growth.

A high-quality molecular biology laboratory allows for the use of molecular cloning techniques for gene expression analysis and the creation of viral vectors used for cell transformation. Flow cytometry, including a cytometer with the ability for multiparametric fluorescence detection, allows for precise characterization of cell antigens and the identification of cell populations and their derivatives.

We are interested in collaboration in research as well as in obtaining funding and research grants. You are welcome to contact us!

Zobacz video galerię

Prof dr hab. Ewa Zuba-Surma & dr E. Karnas: iPSC EVs boost hematopoietic properties of cord blood cells: